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KMID : 1040420150190020159
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Childhood Kidney Diseases
2015 Volume.19 No. 2 p.159 ~ p.166
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Hyponatremia May Reflect Severe Inflammation in Children with Kawasaki Disease
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Lee I-Re
Park Se-Jin
Oh Ji-Young
Jang Gwang-Cheon
Kim Uria
Shin Jae-Il
Kim Kee-Hyuck
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Abstract
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Purpose: The aim of the present study was to investigate the risk factors for the development of coronary artery lesions (CALs) and to determine whether hyponatremia is associated with CALs in children with Kawasaki disease (KD).
Methods: We retrospectively analyzed the data of 105 children with KD who were admitted to Ilsan Hospital between January 2000 and July 2011.
Results: Erythrocyte sedimentation rate (P = 0.013), total bilirubin levels (P = 0.017) were higher and serum sodium levels (P = 0.027) were lower in KD children with CALs than those without. White blood cell (WBC) counts (P = 0.006), neutrophil counts (P = 0.003) were higher and albumin levels (P = 0.009) were lower in KD children with hyponatremia than those without. On multiple logistic regression analysis, hyponatremia (P = 0.024) and intravenous immunoglobulin?resistance (P = 0.024) were independent risk factors for CALs in KD. Furthermore, serum sodium levels were correlated negatively with WBC counts (P = 0.004), neutrophil counts (P < 0.001), total bilirubin levels (P = 0.005) and positively with albumin levels (P = 0.009).
Conclusion: Our study indicates that hyponatremia may reflect severe inflammation in children with KD.
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KEYWORD
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Kawasaki disease, hyponatremia, inflammation, cardiovascular abnormalities
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